High Performance Ion mobility mass spectrometry (IMS-MS)

Ion mobility mass spectrometry (IMS-MS) provides an additional analytical separation dimension as well as the ability for ion selection and filtering based on size-to-charge ratios, ultimately enabling increases in instrument specificity, peak capacity, and dynamic range. This paper showcases the optimized AP-DTIMS-Orbitrap MS system., i Isobaric peptide and sugar isomers were successfully resolved, and the identities of separated species were validated by high-energy collision dissociation experiments.