Isomer Separation

Researchers need to differentiate between isomers to ensure drug safety and efficacy. 

High performance IMS-MS can be used to separate structural isomers, a huge advantage in many stages of pharmaceutical development. 

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Measuring Conformational Structure Change in Molecules

Molecules, specifically proteins can change shape under environmental conditions. This can have an affect on drug safety and performance. Combining HPIMS with a soft ionization source, ions are separated by their size and shape giving researchers the ability to study slight structural differences in molecular ions. Measured collision cross sections can be used to illustrate conformational changes of the molecules.

Proteomics and Metabolomics Studies

Mass spectrometry (MS) based technologies are commonly used to quantify peptides, proteins and metabolites. The technology therefore plays a crucial role in the discovery of new candidate biomarkers. However, despite significant advances, these technologies remain challenged by complex samples. HPIMS, when coupled with mass spec has proven to be a useful technique for increasing the dynamic range and uncovering low-level proteins of potential interest.

High performance ion mobility spectrometry has many benefits for analytical labs:

• High-resolution separation of complex samples
• Optimize your existing investment in mass spectrometry, by adding HPIMS to unlock even more detection power
• Easy to Use
• Cost Effective

Excellims has designed a HPIMS module specifically for researchers who want to add IMS to their existing analytical workflow without investing in a new IMS-mass spectrometer

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• Kaszycki et al., Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high‐resolution drift tube ion mobility and varied drift gas mixtures, Rapid Commun. Mass Spectrom. 2019; 1– 8
• Oranzi et al., Measuring the Integrity of Gas-Phase Conformers of Sodiated 25-Hydroxy-vitamin D3 by Drift Tube, Traveling Wave, Trapped, and High-Field Asymmetric Ion Mobility., Anal. Chem. 2019 Mar 19; 91(6) : 4092-4099
• Kwantwi-Barima et al., Tuning Mobility Separation Factors of Chemical Warfare Agent Degradation Products via Selective Ion-Neutral Clustering, Anal. Chem. 2017, 89, 22, 12416-12424
• Hagan et al., Ion Mobility Spectrometry - High Resolution LTQ-Orbitrap Mass Spectrometry for Analysis of Homemade Explosives, J. Am. Soc. Mass Spectrom. (2017) 28: 1531