Resource Library

Learn More About High Performance Ion Mobility Spectrometry

Keep up-to-date on the latest developments in High Performance Ion Mobility Spectrometry (HPIMS) and Excellims by regularly visiting us here. On this page you will find our comprehensive resources, highlights from new papers and other interesting materials that will help you perform next generation IMS analyses.

Application Notes & White Papers

Benefits of High Performance Ion Mobility Spectrometry (HPIMS) for Cleaning Validation

This paper illustrates the benefits of High Performance Ion Mobility Spectrometry (HPIMS) for Cleaning Validation and how it combats the limitation of existing CV methods.

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High Performance Ion Mobility Spectrometry (HPIMS) for PAT

This paper summarizes HPIMS applications for PAT, showcasing its utility and value for cleaning validation, reaction monitoring, and fermentation monitoring.

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High Performance Ion Mobility Spectrometry (HPIMS) - Applications in Pharmaceutical Manufacturing and Development

This application note summarizes the critical role that high performance ion mobility spectrometry plays in pharmaceutical analyses.

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Publications

Separation of biologically relevant isomers on an Orbitrap mass spectrometer using high-resolution drift tube ion mobility and varied drift gas mixtures

2022

Atmospheric pressure drift tube ion mobility is a powerful addition to the Orbitrap mass spectrometer enabling direct separation of isomers by their size and shape.

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Separations of Carbohydrates with Noncovalent Shift Reagents by Frequency-Modulated Ion Mobility-Orbitrap Mass Spectrometry

2021

In this work, multiplexed drift tube ion mobility-Orbitrap mass spectrometry methods were developed to analyze mixtures of disaccharides modified with noncovalent shift reagents

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Combined secondary electrospray and corona discharge ionization (SECDI) for improved detection of explosive vapors using drift tube ion mobility spectrometry

2019

This paper demonstrates how secondary electrospray corona discharge ionization (SECDI) combines the principles of secondary electrospray ionization (SESI) and corona discharge (CD) to achieve higher sensitivity.

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Product Brochures & Tech Notes

Excellims GA2200 Standalone High Performance Ion Mobility Spectrometer

Unlike unreliable handheld devices and slow lab-based chemical detection systems, companies turn to Excellims’ compact high performance ion mobility spectrometry (HPIMS) instrument, the GA2200, because it provides significant manufacturing savings alongside trustworthy results, fast. Download this product presentation to learn about the accessories available for the GA2200.

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Excellims MA3100 for Thermo Scientific^TM Orbitrap® and Ion Trap Mass Spectrometers

Excellims MA3100 for Thermo Scientific<sup>TM</sup> Orbitrap® and Ion Trap Mass Spectrometers image

HPIMS enables ion mobility to be added to a lab for the fraction of the cost of a new integrated IMS-mass spectrometer. The MA3100 is an independent HPIMS module that integrates with the Thermo Orbitrap, linear ion trap mass spectrometers and other mass spectrometers. Download this product brochure to learn about the MA3100.

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Excellims MC3100 Compact High Performance Ion Mobility Mass Spectrometer

A rugged, portable integrated HPIMS-mass spectrometer, the MC3100 brings two-dimensional chemical detection to address unmet field detection challenges, such as clinical diagnostics.

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Webinars

Establishing a rapid, compliant, specific cleaning validation protocol

Webinar Length: 45 minutes

Webinar Host: Excellims Corporation

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Cleaning Validation Analysis Made Easy

This webinar introduces ion mobility spectroscopy (IMS) as a GMP-compliant alternative to legacy methods for at-line cleaning verification, such as TOC swab analysis and HPLC.

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Smash Analysis Bottlenecks! Ion Mobility Spectrometry for Pharmaceutical Applications

This webinar introduces Excellims' HPIMS-based instruments as a GMP-compliant alternative to legacy methods or a range of applications in pharma.

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Press Releases

Fast, Efficient High Performance Ion Mobility Spectrometry Proves a Compelling PAT for Pharma

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Excellims Corp. and Washington State University Enter into New Worldwide, Exclusive License Agreement for Advanced Ion Mobility Spectrometry – Mass Spectrometry Technology

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Excellims Awarded US Department of Homeland Security Contract to Develop New Explosives Trace Detection (ETD) System

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Posters & Presentations

Extractive Electrospray Ionization Coupled to Atmospheric Pressure DTIMS-MS for Real-Time Analysis of Aerosols

Poster from The University of North Carolina at Chapel Hill describing extractive electrospray ionization coupled to atmospheric pressure DTIMS-MS for real-time analysis of aerosols

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Chirality Induced Gas-Phase Acidity and Conformational Changes in Cysteine-Polyalanine Peptides

University of the Pacific poster on chirality induced gas-phase acidity and conformational changes in cysteine-polyalanine peptides

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Static Ion Gate Frequency Modulation And Voltage Sweeping To Determining Gas-phase Mobility Coefficients

Washington State University poster on static ion gate frequency modulation and voltage sweeping to determining gas-phase mobility coefficients

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Articles & Interviews

Q&A with Herbert H. Hill, Regents Professor, Washington State University

We sat down with Washington State University Professor of 35 years, Herbert H. Hill, who played a vital role in Excellims’ professional success

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