Electrospray ionization with a high-performance ion mobility spectrometery (ESI-HPIMS) for pharmaceutical drug and forensic compounds

Precision, Linearity, and Limit of Detection of an Electrospray Ionization High Performance Ion Mobility Spectrometer

Electrospray Ionization High Performance Ion Mobility Spectrometry (ESI-HPIMS)

This study investigates the analytical performance of an electrospray ionization high performance ion mobility spectrometer (ESI-HPIMS) for pharmaceutical drug and forensically relevant compounds: erythromycin, ibuprofen, phencyclidine, and 3,4-methylene-dioxy-methamphetamine.

The application note explores the sensitivity, linearity and precision of the method.

This Application Note Includes:

Introduction to Electrospray Ionization High-Performance Ion Mobility Spectrometry (ESI-HPIMS)
Exploration of the applications beyond the traditional IMS domain of explosives detection, ESI-HPIMS has been used successfully to detect illicit drugs in forensic applications, as well as additives and contamination in food and beverage samples and cleaning validation in pharma
Attainment of ppb-range detection limits and RSD values of 12% or better, without any of the limitations on molecular size or polarity imposed by HPLC and traditional IMS.