Separation mechanism of chiral impurities, ephedrine and psuedoephedrine, found in amphetamine-type substances using achiral modifiers in the gas phase

Keywords

ion mobility, ion mobility spectrometry, high performance ion mobility spectrometry, ESI, Electrospray Ionization, IMS-MS, Ion mobility mass spectrometry, detection of drugs, ESI-HPIMS, chiral impuritieshttps://www.excellims.com/applications/food-and-drug-safety

HPIMS for the effective separation of chiral molecules

HPIMS for the effective separation of chiral moleculesThis paper reports the use of HPIMS for the effective separation of chiral molecules using achiral modifiers in the gas phase. Straight-chain achiral alcohols of increasing carbon chain length, from methanol to n-octanol, are used as drift gas modifiers in IMS to highlight the mechanism proposed for gas-phase separations of chiral amphetamine-type substances. A complementary computational study showed either "bridged" or "independent" binding. The combined experimental and simulation data support the proposed mechanism for gas-phase chiral separations using achiral modifiers in the gas phase, thus enhancing the potential to conduct fast chiral separations with relative ease and efficiency.

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